The Collagen Binding Protein Cnm Contributes to Oral Colonization and Cariogenicity of Streptococcus mutans OMZ175

The collagen binding protein Cnm contributes to oral colonization and cariogenicity of Streptococcus mutans OMZ175.

Streptococcus mutans is the etiological agent of dental caries and one of the many bacterial species implicated in infective endocarditis. The expression of the collagen-binding protein Cnm by S. mutans has been associated with extraoral infections, but its relevance for dental caries has only been theorized to date. Due to the collagenous composition of dentinal and root tissues, we hypothesiz...

The collagen binding protein Cnm contributes to oral 1 colonization and cariogenicity of Streptococcus mutans 2 OMZ 175

4 James H. Miller, Alejandro Avilés-Reyes , Kathy Scott-Anne, Stacy Gregoire, Gene E. 5 Watson , Edith Sampson, Ann Progulske-Fox , Hyun Koo, William H. Bowen, José A. 6 Lemos 2 and Jacqueline Abranches 2# 7 8 Center for Oral Biology, Department of Microbiology and Immunology, Department of 9 Dentistry, Department of Environmental Medicine, University of Rochester School of Medicine 10 and Dent...

The collagen binding protein Cnm contributes to oral 1 colonization and cariogenicity of Streptococcus mutans 2 OMZ 175 . 3 4

Cariogenicity of Streptococcus mutans Glucan-Binding Protein Deletion Mutants

Streptococcus mutans is a principal etiologic agent in the development of dental caries due to its exceptional aciduric and acidogenic properties, and its ability to adhere and accumulate in large numbers on tooth surfaces in the presence of sucrose. Sucrose-dependent adherence is mediated by glucans, polymers of glucose synthesized from sucrose by glucosyltransferase (Gtf) enzymes. S. mutans m...

Oral Cnm-positive Streptococcus Mutans Expressing Collagen Binding Activity is a Risk Factor for Cerebral Microbleeds and Cognitive Impairment

Cerebral microbleeds (CMBs) are an important risk factor for stroke and dementia. We have shown that the collagen binding surface Cnm protein expressed on cnm-positive Streptococcus mutans is involved in the development of CMBs. However, whether the collagen binding activity of cnm-positive S. mutans is related to the nature of the CMBs or to cognitive impairment is unclear. Two-hundred seventy...